Splenic Enlargement Induced by Preoperative Chemotherapy Is an Useful Indicator for Predicting Liver Regeneration after Resection for Colorectal Liver Metastases

Introduction: Conversion chemotherapy may downsize unresectable colorectal liver metastases (CRLMs), but cause injury and splenic enlargement. The effect of preoperative on regeneration after resection remains undetermined. aim this study was to examine whether enlargement induced by is an indicator identify high-risk patients for impaired dysfunction resection. Methods: We retrospectively reviewed 118 Japanese with CRLMs. Fifty one had conversion chemotherapy. other 67 underwent upfront clarified effects volume, function, postoperative regeneration. Perioperative outcome also analyzed. Results: A ratio the volume before (SP index) in oxaliplatin-based group significantly greater than groups 9 or more cycles. Patients whose SP index 1.2 higher indocyanine green retention rate at 15 min (ICG-R15) without Analyses covariance showed decreased more. incidence Multivariate analysis a significant predictive factor Conclusion: Splenic useful evaluation decision-making tool treatment strategy